Linda La Grange

Personal Information

Office Address:

School of Behavioral Sciences
911 University Ave.
New Mexico Highlands University
Las Vegas, NM 87701
(505) 454-3379 phone
(505) 454-3331 fax
lagrange_l@nmhu.edu

Education

Undergraduate: University of Alaska
BA Elementary Education/Music, 1972

Graduate: New Mexico Highlands University
MS Psychology, 1987

University of Alberta
Ph.D. Psychology, 1989

Primary Research Interests

• Hepatoprotective and fetoprotective properties of flavonoids in treatment of alcohol abuse
• Identification of biological markers of excessive alcohol consumption
• Biochemical correlates of personality traits/pathology

Professional Experience

• 1989-1993 Assistant Professor of Psychology, NMHU
• 1993-1997 Associate Professor of Psychology, NMHU
• 1997-present Professor of Psychology, NMHU
• Summer 1996 On-Site research collaboration at Los Alamos National Laboratories CST-1; FAST Project.
  Contact person, Dr. Chuck Wilkerson. Research consisted of development of HPLC methods to determine contaminants in synthesized inorganic substances.
• 1998-1999 Chair, Department of Behavioral Sciences
• 1999-2004 Associate Dean of Graduate Studies
• Director of Institutional Research
• 2005-Present Interim Associate Dean of the College of Arts and Sciences

Research mentor:
1995-present NIH Bridges Research Mentor (total of 18 students)
WAESO Research Mentor (total of 25 students)
New Mexico Alliance for Minority Participation (AMP) Research Mentor (total of 12 students)

Grants Received

1991-1993 NIH-NIAA RO3 - $100,000/2 years
1994-1997 Herbs Etc., Santa Fe NM - $ 6,000/year
1995-1997 Inverni della Beffa Milan, Italy - $ 6,000/year
1997-1998 Inverni della Beffa, Milan, Italy - $ 9,000/year
1998-1999 Inverni della Beffa, Milan, Italy - $ 12,000/year
1999-2000 Inverni della Beffa, Milan, Italy - $ 12,000/year
2000-2003 NIH/Bridges PD - $ 540,000/3 years
1999-2001 NIH-NIAA R21 - $ 176,000/2 years
2004-2005 Council of Graduate Schools - $ 4,000/1 year
1999-2004 WAESO - $ 7,760/year

Professional Service

NIH P20 Review Panel EXPORT Summer; 2002; 2003
NIH Loan Repayment Program for Health Disparities Research Review Panel Spring; 2004
NIH R24 Review Panel EXPORT Summer; 2004
NIH T37 MHIRT International Research Training Program Spring; 2005
New Mexico Council of Graduate Deans; 1999-2004
New Mexico Alliance for Graduate Education and the Professoriate (AGEP); 2000-2005
NMHU NCA Committee; 1998-Present
NMHU Strategic Planning Committee – Core Group; 2003-Present
New Mexico Performance Effectiveness Planning Committee; 2002-2004
New Mexico Mental Health Initiatives Panel; 2003-Present
Expert Witness for Criminal Drug/Alcohol Cases; 2005

Professional Societies

Research Society on Alcoholism
Society for Individual Differences
American Association of University Professors (AAUP)
New Mexico State Treasurer 1999-2000

Honor Societies

Phi Kappa Phi
Sigma Xi

Abstracts

Schreiber, H., Ortiz, M., Marquez, W., Garcia, M., Gonzalez, M., Maez, C., Klein, R., Bibb, M., & Calhoon, L. (1987). Early preweaning maternal behavior influences the sensitization of amphetamine-induced stereotypy following haloperidol administration in the adult offspring. Abstracts of Society of Neuroscience, 13, 221.
Calhoon, L. (1991). Space, time, and attention: Processing of stimuli delivered to the hands. Journal of Rehabilitation Research and Development, 28, 68.

Presented Papers

Calhoon, L., Ortiz, M., Marquez, W., Garcia, M., Gonzalez, M., Maez, C., Klein, R., Bibb, M., & Schreiber, H. (1987). Early preweaning nestcage disturbance influences adult dopaminergic function through alterations in maternal behavior. International Society for Developmental Psychobiology, New Orleans, LA.
Calhoon, L. (1988). Time, space, laterality and strategy in tactual processing. Joseph R. Royce Research Conference, Edmonton, AB, Canada
Calhoon, L. & Lechelt, E. (1989). Laterality in tactile temporal processing. Western Canada Psychological Association, Alberta, Canada
La Grange, L., Anton, R., Crow, H., & Garcia, S. (1993). Carbohydrate-deficient transferrin: values for Southwestern U.S. Hispanic college students. Research Society on Alcoholism, San Antonio, TX
La Grange, L., Anton, R., Garcia, S., & Herrbold, C. (1994). Oral contrceptives and levels of carbohydrate-deficient transferrin (CDT) in a young female population. Research Society on Alcoholism, Maui, Hawaii.
Wang, M., La Grange, L., Reyes, E., & Tao, J. (1995). Silibum marianum extract: A hepatoprotective agent as measured by ethanol-induced enzyme activity in rats. Research Society on Alcoholism, Steamboat Springs, CO.
Yeastedt, J., La Grange, L., & Anton, R. (1995). Detecting relapse in female alcoholics using CDT levels and GGTP activity. Research Society on Alcoholism, Steamboat Springs, CO.
Yeastedt, J., & La Grange, L. (1995). Serum transaminases as biochemical markers of relapse in female alcoholics. American Psychological Association, New York, NY.
Matykiewicz, L., La Grange, L., Vance, P., & Wang, M. (1996). Biological correlates of aggression-hostility: Adjudicated males vs. control males. Rocky Mountain Psychological Association. Park City, UT.
Edwards, J., Wang, M., Pecore, N., & La Grange, L. (1998). The LD50 of kavalactones extracted from Piper methysticum in rats. Experimental Biology ’98. San Francisco, CA.
Reid, C., Edwards, J., Wang, M., Manybeads, Y., Mike, L., Martinez, N., & La Grange, L. (1998). Fetal rat exposure to EtOH: Protective effects of silymarin on learning and memory. Experimental Biology ’98. San Francisco, CA.
La Grange, L., Manybeads, Y., Mike, L., Martinez, N., Korte, H., Baca, E., Reid, C., & Wang, M. (1998). Fetoprotective effects in rats of silymarin against in utero exposure to ethanol. Experimental Biology ’98. San Francisco, CA.
J. Edwards, R, Madrid, C. Ortiz, S. Burge, M. Wang, J. Niemi, H. Soos, & L. La Grange (1998). Prenatal exposure to ethanol in rats: Protective effects of the bioflavonoid, silymarin. The American College of Toxicology '98, Orlando FA.
J. Edwards, R. Madrid, C. Ortiz, S. Burge, M. Wang, J Niemi, H. Soos, & L. La Grange (1998). Chronic use of kava: Does it affect rat performance during active avoidance testing? The American College of Toxicology '98, Orlando FA.
Z. Ding, J. Edwards, & L. La Grange (2000). Protective effect of silymarin and silibinin on ethanol-induced cell injuries in the human G2 cell line. International Behavioral Neuroscience Society, Denver, CO
G. Benally, A. Charley, P. James, L. Gonzales, J. Edwards, & L. La Grange (2000). Does the chronic administration of kava enhance cognitive functioning in rats during radial arm maze testing? International Behavioral Neuroscience Society, Denver CO.
A. Busby, J. Edwards, M. Wang, J. King, & L. La Grange (2000). Prevention of ethanol-induced social learning and visio-spatial deficits by Siliphosâ in a rat model of
fetal alcohol syndrome. International Behavioral Neuroscience Society, Denver, CO.
Z.Y. Ding, H., H. Sonchar, B. Zhang, J. Edwards, & L. La Grange (2000). The effect of silybin on ethanol-induced cytotoxicity in Hep G2 cells. The American College of Toxicology ’00, San Diego CA.
Z. Ding, E. Klein, E., B. Zhang, J. Edwards, M. Houston, L. La Grange (2001). An improved method for assays of oxidative stress in tissues using an automated microplate reader. AAAS 2001, San Fransisco, CA.
N.M. Moreland, R.S. Montoya, & L. La Grange (2001). Fetal alcohol syndrome and laterality: The fetoprotective effects of silymarin. Neuroscience 2001. San Diego, CA.

Symposia

Underlying mechanisms of the fetoprotective activity of silymarin. Presented by: A. Busby, J. Edwards, M. Huston, & L. La Grange. Neurochemistry Winter Conference 2000, Sölden, Austria.

Publications (Refereed Journals)

Calhoon, L., (1988). Explorations into the biochemistry of sensations seeking. Personality and Individual Differences, 9, 941-949.
Calhoon, L. (1991). Sensation seeking, exercise, and dopamine beta hydroxylase. Personality annd Individual Differences, 12, 903-907.
Calhoon-La Grange, L., Jones, T., Reyes, E., & Ott, S. (1993). Monoamine oxidase levels in females: Relationships to sensation seeking, alcohol use, physical fitness, and menstrual cycle. Personality and Individual Differences, 12, 439-446.
La Grange, L., Anton, R., Crow, H., & Garcia, S. (1994). Correlates of GGTP and CDT with self-reported levels of alcohol consumption among college students. Alcoholism: Clinical and Experimental Research, 18, 653-656.
La Grange, L., Jones, T., Erb, L., & Reyes, E. (1995). Biochemical correlates of alcohol use in a student population. Addictive Behaviors, 20, 93-103.
La Grange, L., Anton, R., Garcia, S., & Herrbold, C. (1995). Oral contraceptives and CDT values in a female population. Alcoholism: Clinical and Experimental Research, 19, 100-103.
Wang, M., La Grange, L., Reyes, E., & Tao, J. (1996). Hepatoprotective properties of milk thistle extract as measured by ethanol-induced enzyme activity in rat model. Fitoterapia, 67, 166-171.
Matykiewicz, L., La Grange, L., Vance, P., Wang, M., & Reyes, E. (1997). Adjudicated adolescent males: Measures of urinary 5-hydroxyindoleacetic acid and reactive hypoglycemia. Personality and Individual Differences, 33, 327-332.
Matykiewicz, L., La Grange, L., Reyes, E., Vance, P., & Wang, M. (1997). Adolescent Males, Impulsive/Aggressive behavior, and Alcohol Abuse: Biological Correlates. Journal of Child and Adolescent Substance Abuse, 6, 27-37.
Yeastedt, J., La Grange, L. & Anton, R. (1998). Female alcoholic outpatients and female college students: A correlational study of self-reported alcohol consumption and carbohydrate-deficient transferrin levels. Journal of Studies on Alcohol, 59, 555-559.
Talbot, R., & La Grange, L. (1999). The effects of salty and nonsalty food on peak breath alcohol concentration and divided attention task performance in females. Substance Abuse
La Grange, L., Wang, M., Watkins, R., Ortiz, D., Sanchez, M., Konst, J., Lee, C., & Reyes, E. (1999). Fetal protective effects of the flavonoid mixture, silymarin, on fetal rat brain and liver. Journal of Ethnopharmacology, 65, 53-61.
Reid, C., Edwards, J., Wang, M., Manybeads, Y., Mike, L., Martinez, N., La Grange, L., & Reyes, E. (1999). Prevention of ethanol-induced social learning deficits in rats. Planta Medica, 65, 421-424.
Edwards, J., La Grange, L., Wang, M., & Reyes, E. (2000). Fetoprotectivity of the flavanolignan compound siliphos against ethanol-induced toxicity. Phytotherapy Research, 14, 517-521.
Busby, A., La Grange, L., & Edwards, J. (2002). The Use of a Silymarin/Phospholipid Compound as a Fetoprotectant from Ethanol-Induced Behavioral Deficits. Journal of Herbal Pharmacotherapy, 2, 39-47.
Ding, Z., La Grange, L., & Edwards, J. (2003). Protective Effects of Silymarin and Silybin on Ethanol-Induced Toxicity in Hep G2 Cells. Journal of Ethnopharmacology.
La Grange, L., Ding, Z., Houston, M., & Klein, E. (2003). Normalizing Effects of Bioflavonoids on EtOH-Induced Indices of Lipid peroxidation in Rat Neonates and Dams. Pharmaceutical Biology.
Moreland, N., La Grange, L., & Montoya, R. (2002). Impact of In Utero Exposure to EtOH on Corpus Callosum Development and Paw Preferences in Rats: Protective Effects of Silymarin. BMC Complementary and Alternative Medicine, 2, 10.
Neese, S., La Grange, L., Trujillo, E., & Romero, D. (2004). The effects of ethanol and silymarin treatment during gestation on spatial working memory. BMC Complementary and Alternative Medicine, 4, 10.

Publications (Lay Journals)

Calhoon, L. (1991). Need tests for women drinkers. The U.S. Journal, 8.
La Grange, L. (1992) Beta-carbolines and alcoholism: associations and implications. Science Matters, 3, 17.
La Grange, L. (1996). A natural tonic for liver disease? Science Matters, 2, 18.
La Grange, L. (2005). Oshà, Yerba del a Gente, Native Plant Society Newsletter, September, 2005.

Book Chapter

La Grange, L. (1994). Gender differences in biological markers of alcohol use. In R. Watson (Ed.) Addictive Behaviors in Women, pp. 125-158, Humana Press: NJ